NIH Library of Medicine PubMed Central
Journal List > Med Gas Res > v.13(3): Jul-Sep 2023 > PNC9979207
The review article titled “Molecular Hydrogen Therapy for Neurological Diseases: A Review of Current Evidence” discusses the potential therapeutic application of molecular hydrogen in treating various neurological diseases. The article highlights the role of oxidative stress and reactive oxygen species in the pathogenesis of neurological disorders. Molecular hydrogen therapy is presented as a promising approach due to its unique ability to selectively scavenge harmful free radicals while sparing essential reactive oxygen species.
The review covers animal and clinical studies that demonstrate the neuroprotective effects of hydrogen therapy in different neurological conditions, including stroke, neurodegenerative diseases, neurotrauma, and global brain injury.
The introduction outlines the significance of molecular hydrogen in scavenging reactive oxygen species and its potential therapeutic benefits. It emphasizes the relevance of oxidative stress in neurological diseases and the role of molecular hydrogen in addressing this issue.
The article details the delivery methods of hydrogen therapy, including inhalation of hydrogen gas, intravascular hydrogenized saline infusions, and orally consuming hydrogen water. It also discusses various studies that have investigated the distribution and effects of hydrogen based on different administration methods.
The review then delves into specific neurological conditions:
- Stroke: The review presents findings from animal models and clinical studies on ischemic stroke. It discusses hydrogen therapy’s potential to reduce reperfusion injury, improve neurobehavioral outcomes, and alleviate oxidative stress.
- Intracerebral Hemorrhage: The potential neuroprotective effects of hydrogen therapy in animal models of hemorrhagic stroke are highlighted, although clinical studies in this context are lacking.
- Subarachnoid Hemorrhage (SAH): The article discusses the role of hydrogen therapy in reducing oxidative stress, inflammation, and neuronal apoptosis in SAH models. Some ongoing human studies are mentioned, evaluating the effects of hydrogen therapy in SAH patients.
- Neurodegenerative Diseases: The review discusses the beneficial effects of hydrogen therapy in animal models of Parkinson’s and Alzheimer’s diseases. It also includes a clinical trial demonstrating improved outcomes in Parkinson’s patients receiving hydrogen water therapy.
- Neurotrauma: The potential neuroprotective effects of hydrogen therapy in traumatic brain injury (TBI) are discussed. Although larger clinical studies are lacking, anecdotal evidence suggests potential benefits in TBI cases.
- Global Brain Injury: The article presents studies on hydrogen therapy’s effects in septic encephalopathy and global brain ischemia/reperfusion models.
The conclusion underscores the significant positive outcomes observed in preclinical and clinical studies of hydrogen therapy for neurological diseases. While more human studies are needed to further validate its efficacy, the review highlights hydrogen therapy’s potential as an adjunctive treatment option for a wide range of neurological conditions . Notably, the article emphasizes the lack of reported adverse effects associated with hydrogen therapy in the reviewed studies.
分子氫療法治療神經系統疾病：對當前證據的回顧
題為“神經系統疾病的分子氫療法：當前證據的回顧”的評論文章討論了分子氫在治療各種神經系統疾病中的潛在治療應用。該文章強調了氧化應激和活性氧在神經系統疾病發病機制中的作用。分子氫療法因其獨特的選擇性清除有害自由基同時保留必需的活性氧的能力而被認為是一種有前途的方法。
該綜述涵蓋了動物和臨床研究，這些研究證明了氫療法對不同神經系統疾病（包括中風、神經退行性疾病、神經外傷和全腦損傷）的神經保護作用。
簡介概述了分子氫在清除活性氧方面的重要性及其潛在的治療益處。它強調了氧化應激與神經系統疾病的相關性以及氫分子在解決這一問題中的作用。
文章詳細介紹了氫療法的輸送方法，包括吸入氫氣、血管內輸注氫化鹽水和口服氫水。它還討論了基於不同管理方法調查氫的分佈和影響的各種研究。
然後，該評論深入研究了特定的神經系統疾病：
中風：該綜述介紹了缺血性中風動物模型和臨床研究的結果。它討論了氫療法減少再灌注損傷、改善神經行為結果和減輕氧化應激的潛力。
腦出血：氫療法對出血性中風動物模型的潛在神經保護作用受到重視，儘管缺乏這方面的臨床研究。
蛛網膜下腔出血(SAH)：本文討論了氫療法在減少SAH 模型中氧化應激、炎症和神經元凋亡方面的作用。提到了一些正在進行的人體研究，評估氫療法對SAH 患者的效果。
神經退行性疾病：該綜述討論了氫療法對帕金森病和阿爾茨海默病動物模型的有益影響。它還包括一項臨床試驗，證明接受氫水治療的帕金森病患者的治療效果有所改善。
神經創傷：討論了氫療法對創傷性腦損傷(TBI) 的潛在神經保護作用。儘管缺乏更大規模的臨床研究，但軼事證據表明TBI 病例具有潛在的益處。
全球腦損傷：本文介紹了氫療法對膿毒性腦病和全球腦缺血/再灌注模型的影響的研究。
結論強調了氫療法治療神經系統疾病的臨床前和臨床研究中觀察到的顯著積極結果。雖然需要更多的人體研究來進一步驗證其功效，但該評論強調了氫療法作為多種神經系統疾病的輔助治療選擇的潛力。值得注意的是，該文章強調在審查的研究中缺乏與氫療法相關的不良反應的報導。