NIH Library of Medicine PubMed Central
Journal List Front Pharmacol PMC3108576
Numerous studies have demonstrated the protective effects of hydrogen (H2) against ROS-induced diseases. By effectively eliminating •OH and •ONOO–, H2 has been shown to mitigate lipid and DNA peroxidation, enhance cellular antioxidant capacity, and provide protection against oxidative damage to cells. The human body contains various ROS, including O2•–,•OH, H2O2, NO•,•ONOO–, among others. Under normal conditions, cells can maintain a balance between ROS formation and removal through specific enzymatic pathways or antioxidants. However, under pathological conditions, this balance is disrupted, leading to oxidative stress and various diseases such as chronic obstructive pulmonary disease (COPD). Studies indicate that ROS plays a crucial role in COPD development, and certain antioxidants are effective in protecting against the harmful effects of oxidative stress. Based on its unique ability to eliminate toxic ROS, we propose that hydrogen therapy may represent a novel and effective treatment for COPD.
氫氣（H2）對於受到ROS引發疾病的保護效果已經被眾多研究所證實。通過有效清除•OH和•ONOO–，H2已被證明可以減緩脂質和DNA的過氧化反應，增強細胞的抗氧化能力，進而保護細胞免受氧化損害。人體內包含多種ROS，包括O2•–，•OH，H2O2，NO•，•ONOO–等。在正常情況下，細胞能夠通過特定的酶途徑或抗氧化劑維持ROS形成和清除之間的平衡。然而，在某些病理條件下，這種平衡被打破，導致氧化壓力和各種疾病，如慢性阻塞性肺病（COPD）。研究顯示ROS在COPD發展中發揮了至關重要的作用，某些抗氧化劑對於保護免受氧化應激的有害影響是有效的。基於氫氣具有清除有毒ROS的獨特能力，我們提出氫療法可能是COPD的一種新穎且有效的治療方法。
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