DOI: https://doi.org/10.7861/clinmed.2020-0370 Clin Med March 2021
Hydrogen therapy holds great promise as a treatment for various diseases due to its gentle properties, strong affinity, and inherent safety. However, there is limited discussion on the current application of hydrogen therapy in liver diseases. This article presents the administration of hydrogen and the mechanisms involved in in vivo hydrogen therapy. It covers aspects such as the modulation of reactive oxygen species, apoptosis, autophagy, inflammation, impact on mitochondria, and the role of protein transporters. The primary emphasis is on the clinical use of hydrogen and its associated mechanisms in liver dysfunction or diseases, including non-alcoholic fatty liver disease, hepatitis B, liver dysfunction resulting from liver tumors, and colorectal tumor chemotherapy. Additionally, the article explores the application of hydrogen ex vivo for liver protection. Lastly, it delves into the current and future challenges of hydrogen therapy in liver diseases, with the goal of enhancing understanding and offering insights into this evolving field.
氫療法由於其溫和的特性、高親和力和天然的生物安全性，對多種疾病的治療具有巨大潛力。然而，目前對於氫療法在肝臟疾病中的應用的討論相對較少。本文介紹了氫的給藥方式以及體內氫療法的機制，包括調節氧自由基、細胞凋亡和自噬、炎症、影響細胞色素以及蛋白質運輸體等方面。主要重點放在臨床上使用氫以及其在肝臟功能障礙或疾病中的相關機制，包括非酒精性脂肪肝、乙型肝炎、由肝腫瘤引起的肝功能障礙，以及結直腸腫瘤的化療。此外，文章還揭示了體外氫在保護肝臟方面的應用。最後，文章討論了氫療法在肝臟疾病中的現在和未來挑戰，旨在提升對氫療法的認識並為這個不斷發展的領域提供一些見解。
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