Journal List J Zhejiang Univ Sci B v.23(2); 2022 Feb 15 PMC8861563
J Zhejiang Univ Sci B. 2022 Feb 15; 23(2): 102–122.
Chinese. doi: 10.1631/jzus.B2100420
Molecular hydrogen exerts a range of biological effects on almost all organs, showcasing anti-oxidative, anti-inflammatory, and anti-aging properties, while also contributing to the regulation of autophagy and cell death. The lungs, serving as the primary organ for gas exchange, are continually exposed to various harmful environmental irritants. Exposure, whether short- or long-term, to these detrimental substances often leads to lung injuries, resulting in respiratory and lung diseases. Acute and chronic respiratory ailments pose significant global public health challenges due to their elevated rates of morbidity and mortality. The coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has emerged as a worldwide pandemic.
An expanding body of research indicates that hydrogen may play a protective role against diverse lung diseases, encompassing acute lung injury, chronic obstructive pulmonary disease, asthma, lung cancer, pulmonary arterial hypertension, and pulmonary fibrosis. This review aims to underscore the multifaceted functions of hydrogen and elucidate the mechanisms underpinning its protective effects in various lung diseases. Emphasis is placed on hydrogen’s roles in disease pathogenesis and its clinical significance.
分子氫對幾乎所有器官均產生生物效應，展現出抗氧化、抗發炎和抗衰老的特性，同時有助於調節自噬和細胞死亡。作為氣體交換的主要器官，肺臟不斷受到各種有害的環境刺激。短期或長期暴露於這些有害物質通常導致肺損傷，引起呼吸系統和肺部疾病。急性和慢性呼吸系統疾病的發病率和死亡率極高，已成為全球主要的公共衛生關切點。例如，由嚴重急性呼吸系統綜合症冠狀病毒2（SARS-CoV-2）引起的2019冠狀病毒病（COVID-19）已成為全球大流行。越來越多的研究表明，氫氣可能保護肺部免受各種疾病的侵害，包括急性肺損傷、慢性阻塞性肺疾病、哮喘、肺癌、肺動脈高壓和肺纖維化等。本文詳細介紹了氫氣的多重功能以及其在各種肺部疾病中的保護效應的機制，重點關注其在疾病發生機制和臨床意義中的作用。