NIH Library of Medicine PubMed Central
Journal List Pharmaceuticals (Basel) PMC10057981
(1) Background: Alzheimer’s disease (AD) is a progressive and fatal neurodegenerative disorder. Hydrogen gas (H2) is a therapeutic medical gas known for its multifunctional properties, including anti-oxidant, anti-inflammatory, anti-cell death, and the stimulation of energy metabolism. This open-label pilot study on H2 treatment was conducted with the aim of developing a disease-modifying treatment for AD through multifactorial mechanisms.
(2) Methods: Eight patients with AD inhaled 3% H2 gas for one hour twice daily for 6 months and were subsequently followed for 1 year without inhaling H2 gas. Clinical assessments were conducted using the Alzheimer’s Disease Assessment Scale-cognitive subscale (ADAS-cog). Neuron integrity was objectively assessed using diffusion tensor imaging (DTI) with advanced magnetic resonance imaging (MRI) applied to neuron bundles passing through the hippocampus.
(3) Results: The mean individual ADAS-cog change exhibited significant improvement after 6 months of H2 treatment (-4.1) compared to untreated patients (+2.6). DTI assessment revealed that H2 treatment significantly enhanced the integrity of neurons passing through the hippocampus compared to the initial stage. The improvements observed through ADAS-cog and DTI assessments were maintained during the follow-up after 6 months (significantly) or 1 year (non-significantly).
(4) Conclusions: This study suggests that H2 treatment not only provides relief for temporary symptoms but also exerts disease-modifying effects, notwithstanding its limitations.
(1) 背景：阿茲海默症（AD）是一種漸進且致命的神經退行性疾病。氫氣（H2）是一種具有多重功能的治療性醫用氣體，包括抗氧化、抗發炎、抗細胞死亡和促進能量代謝等。為了通過多因素機制開發AD的疾病修飾性治療，進行了一項有關H2治療的開放標籤試驗。
(2) 方法：八名AD患者每天吸入3%的H2氣體，每次一小時，為期6個月，然後在未吸入H2氣體的情況下進行1年的隨訪。使用阿茲海默症評估量表-認知亞量表（ADAS-cog）對患者進行臨床評估。為了客觀評估神經元完整性，應用了擁有通過海馬區的神經元束的先進磁共振擴散張量成像（DTI）技術。
(3) 結果：平均個體ADAS-cog變化在H2治療後6個月顯著改善（-4.1），相較於未治療的患者（+2.6）。根據DTI評估，H2治療顯著改善了通過海馬區的神經元的完整性，相對於初始階段。通過ADAS-cog和DTI評估觀察到的改善在6個月後（顯著）或1年後（非顯著）的隨訪期間得以保持。
(4) 結論：本研究表明，儘管存在限制，H2治療不僅緩解了暫時的症狀，還具有疾病修飾性效
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