Nature > Scientific Reports > Articles > Article number: 20173 (2020) 

In a recent clinical study, it was demonstrated that incorporating hydrogen (H2) into the dialysate during haemodialysis improves blood pressure control in individuals with end-stage kidney disease. In this study, we investigated the potential beneficial impact of H2 on hypertension using animal models. Rats with 5/6 nephrectomy were exposed to either H2 (1.3% H2 + 21% O2 + 77.7% N2) or a control gas mixture (21% O2 + 79% N2) for 1 hour daily. The results showed that H2 significantly attenuated the increase in blood pressure following 5/6 nephrectomy. This anti-hypertensive effect was also evident in rats with established hypertension three weeks post-nephrectomy. Continuous blood pressure monitoring using an implanted telemetry system revealed that H2 exerted its anti-hypertensive effect not only during daytime rest but also during nocturnal activities. Spectral analysis of blood pressure variability indicated that H2 improved autonomic imbalance by suppressing an overly active sympathetic nervous system and enhancing parasympathetic nervous system activity, concurrent with the blood pressure-lowering effect. In conclusion, daily exposure to H2 for 1 hour demonstrated an anti-hypertensive effect in an animal model of hypertension.

最近的臨床研究顯示,在血液透析過程中使用含有氫(H2)的洗腎液能夠改善末期腎臟病患者的血壓控制。在這裡,我們檢驗了H2對動物模型高血壓的有益影響。我們讓5/6腎切除的大鼠吸入H2(1.3%H2 + 21%O2 + 77.7%N2)或對照組(21%O2 + 79%N2)的氣體混合物,每天1小時。結果顯示,H2明顯抑制了5/6腎切除後血壓的增加。這種抗高血壓作用也在腎切除後3週處於穩定高血壓狀態的大鼠中得到確認。為了詳細研究H2對高血壓的影響,我們使用植入的遙測系統連續監測血壓。H2不僅在白天休息期間表現出抗高血壓作用,而且在夜間活動期間也同樣有效。血壓變異的頻譜分析顯示,H2改善了自主神經系統不平衡,即通過抑制過度活躍的交感神經系統和增強副交感神經系統活動,這些效應與降低血壓的效果同時發生。總之,每天暴露於H2 1小時對高血壓的動物模型具有抗高血壓效果。

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