NIH Library of Medicine PubMed Central

Journal List  J Clin Med Res  v.12(10); 2020 Oct  PMC7524558

Background: Molecular hydrogen (H2) stands out as a biologically active gas widely used in the healthcare sector. Recently, hospitals, clinics, beauty salons, and fitness clubs have introduced on-site H2 gas generators, which produce high-purity H2 through water electrolysis, owing to their ease of use. Typically, these generators produce H2 at a low flow rate, raising concerns among physicians about ensuring an effective blood concentration of H2 when delivering the gas through a nasal cannula. This study aims to assess blood concentrations of H2 delivered from an H2 gas generator via a nasal cannula.

Methods: Administering 100% H2, produced by an H2 gas generator, at a low-flow rate of 250 mL/min through a nasal cannula to three spontaneously breathing micro miniature pigs was conducted. An oxygen mask was placed over the nasal cannula to administer oxygen and minimize H2 leakage. A catheter inserted into the carotid artery monitored arterial blood H2 concentration.

Results: In the initial hour of H2 inhalation, the mean (standard error (SE)) H2 concentrations and saturations in the arterial blood of the three pigs were 1,560 (413) nL/mL and 8.85% (2.34%); 1,190 (102) nL/mL and 6.74% (0.58%); and 1,740 (181) nL/mL and 9.88% (1.03%), respectively. These values align with the expected concentration if 100% of the H2 released from the H2 gas generator is absorbed by the body.

Conclusions: Even at low-flow rates, the inhalation of 100% H2 produced by an H2 gas generator can elevate blood H2 concentrations to levels demonstrated to be therapeutically effective in previous non-clinical and clinical studies. The use of a nasal cannula combined with an oxygen mask proves to be a convenient method for minimizing H2 leakage while ensuring proper oxygenation.

背景: 分子氫(H2)是一種在醫療領域廣泛使用的生物活性氣體。近年來,由於其使用便利性,許多醫院、診所、美容院和健身俱樂部紛紛引入現場H2氣體發生器,通過水電解產生高純度的H2。一般來說,這些發生器以低流量產生H2,因此醫生擔心當通過鼻套將氣體傳遞時可能無法確保有效的H2血液濃度。因此,本研究旨在評估由H2氣體發生器通過鼻套傳遞的H2血液濃度。

方法: 我們使用H2氣體發生器產生的100%H2以250 mL/min的低流量通過鼻套對三隻自主呼吸的微小豬進行了實驗。在鼻套上放置氧氣面罩以給予氧氣並減少H2的泄漏。插入頸動脈的導管監測動脈血H2濃度。

結果: 在H2吸入的初始一小時內,三隻豬的動脈血中的平均(標準誤差(SE))H2濃度和飽和度分別為1,560(413)nL/mL和8.85%(2.34%);1,190(102)nL/mL和6.74%(0.58%);以及1,740(181)nL/mL和9.88%(1.03%)。這些數值與預期的濃度一致,即如果100%從H2氣體發生器釋放的H2被人體吸收。

結論: 即使在低流量的情況下,通過H2氣體發生器產生的100%H2吸入可以提高血液中的H2濃度,達到先前非臨床和臨床研究證明具有治療效果的水平。使用鼻套搭配氧氣面罩是一種方便的方法,可減少H2泄漏並確保適當的氧合。

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