NIH Library of Medicine PubMed Central
Journal List Neurosci Bull v.37(3); 2021 Mar PMC7954968
Molecular hydrogen (H2) is a gas with physiological inertness. Despite this, over the past decade, increasing evidence has unveiled its biological functions, particularly under pathological conditions. H2 exhibits protective effects against various diseases, notably those related to the nervous system, such as ischemia/reperfusion injury, traumatic injury, subarachnoid hemorrhage, neuropathic pain, neurodegenerative diseases, cognitive dysfunction resulting from surgery and anesthesia, anxiety, and depression. Its protective roles primarily involve anti-oxidation, anti-inflammation, anti-apoptosis, regulation of autophagy, and preservation of mitochondrial function and the blood-brain barrier. Furthermore, H2 is user-friendly, and its neuroprotective effects come with minimal side effects, suggesting its potential as a therapeutic strategy in clinical settings. This summary encompasses H2 donors and their pharmacokinetics, reviewing the effectiveness and safety of H2 in treating various nervous system diseases based on preclinical and clinical studies. The findings lead to the conclusion that H2 can be a straightforward and effective clinical therapy for CNS diseases like ischemia-reperfusion brain injury, Parkinson’s disease, and conditions characterized by cognitive dysfunction. The potential mechanisms contributing to the neuroprotective effect of H2 are also explored.
分子氫（H2）是一種生理上惰性的氣體。然而，在過去的10年中，越來越多的證據揭示了其在病理條件下的生物學功能。更具體地說，H2對各種疾病，尤其是神經系統疾病，具有保護作用，包括缺血/再灌注損傷，創傷損傷，硬膜外出血，神經性疼痛，神經退行性疾病，手術和麻醉引起的認知功能障礙，焦慮和抑鬱。此外，H2主要通過抗氧化、抗炎、抗凋亡、調節自噬以及保存粒線體功能和血腦屏障發揮保護作用。此外，H2易於使用，具有無明顯副作用的神經保護效果，表明H2管理在臨床環境中是一種潛在的治療策略。在這裡，我們總結了H2供體及其藥代動力學。同時，我們根據臨床前和臨床研究回顧了H2在治療各種神經系統疾病中的有效性和安全性，得出的結論是H2可以是一種簡單而有效的中樞神經系統疾病治療方法，例如缺血再灌注腦損傷，帕金森病和以認知功能障礙為特徵的疾病。還分析了H2神經保護效果的潛在機制。
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