NIH Library of Medicine PubMed Central

Journal List > Molecules > PMC10707987

Hydrogen gas (H2), recognized for its antioxidant properties, has undergone extensive evaluation in vitro, animal studies, and human trials across a spectrum of therapeutic applications. A comprehensive exploration using various medical databases yielded over 2000 publications on hydrogen gas as a potential novel drug substance. Simultaneously, a parallel inquiry into clinical trial registers revealed a plethora of ongoing trials, showcasing the diverse landscape of hydrogen therapy investigations. This review systematically examines and deliberates upon the current insights gleaned from 81 identified clinical trials and 64 scientific publications pertaining to human studies on hydrogen therapy.

Positive outcomes have emerged in pivotal disease areas, encompassing cardiovascular diseases, cancer, respiratory disorders, central nervous system ailments, infections, and more. The review delves into the available administration methods, acknowledging the challenges posed by hydrogen’s explosive hazards and low solubility. Additionally, innovative technologies that may potentially address these challenges in the future are explored.

In conclusion, this review contemplates the prospect of hydrogen gas evolving into a new drug substance in clinical practice. Key considerations include the potential administration forms and clinical indications, with an exploration of whether hydrogen gas could emerge as a transformative element in future medical interventions.


Click here for original article