NIH Library of Medicine PubMed Central
Journal List > Molecules > PMC10707987
Hydrogen gas (H2), recognized for its antioxidant properties, has undergone extensive evaluation in vitro, animal studies, and human trials across a spectrum of therapeutic applications. A comprehensive exploration using various medical databases yielded over 2000 publications on hydrogen gas as a potential novel drug substance. Simultaneously, a parallel inquiry into clinical trial registers revealed a plethora of ongoing trials, showcasing the diverse landscape of hydrogen therapy investigations. This review systematically examines and deliberates upon the current insights gleaned from 81 identified clinical trials and 64 scientific publications pertaining to human studies on hydrogen therapy.
Positive outcomes have emerged in pivotal disease areas, encompassing cardiovascular diseases, cancer, respiratory disorders, central nervous system ailments, infections, and more. The review delves into the available administration methods, acknowledging the challenges posed by hydrogen’s explosive hazards and low solubility. Additionally, innovative technologies that may potentially address these challenges in the future are explored.
In conclusion, this review contemplates the prospect of hydrogen gas evolving into a new drug substance in clinical practice. Key considerations include the potential administration forms and clinical indications, with an exploration of whether hydrogen gas could emerge as a transformative element in future medical interventions.
氫氣（H2）以其抗氧化特性而受到廣泛評估，包括體外研究、動物實驗以及人體試驗，涵蓋了多種治療應用領域。通過在各種醫學數據庫中進行簡單的“氫氣”搜索，發現了超過2000篇與氫氣作為潛在新藥物有關的出版物。在臨床試驗註冊中進行平行搜索也產生了眾多結果，反映了涉及氫療法的正在進行的臨床試驗的多樣性。這篇綜述旨在評估和討論81個已確定的臨床試驗和64篇人體研究科學出版物中有關氫療法的當前研究發現。積極的指標已在主要疾病領域中找到，包括心血管疾病、癌症、呼吸系統疾病、中樞神經系統疾病、感染等等。該綜述還檢討了現有的管理方法，由於氫氣的爆炸危險和低溶解度可能帶來的挑戰，以及可能的未來創新技術來減輕這些挑戰。最後，陳述了對研究發現進行深入討論，以解答以下問題：氫氣是否會成為未來臨床實踐中的新藥物？如果是，可能的管理形式和臨床指示是什麼？