NIH Library of Medicine PubMed Central

Journal List  Front Aging Neurosci  PMC10020224

With the ongoing trend of an aging population, Alzheimer’s disease (AD) has emerged as a pressing global medical concern. Cognitive decline in individuals with AD results in a diminished capacity for daily activities, coupled with behavioral and personality abnormalities, leading to disruptive psychiatric symptoms that significantly impact patients’ daily lives. Presently, pharmaceutical interventions are the primary approach in clinical management of AD; however, a substantial number of patients experience ineffectiveness of drugs, and some medications even induce severe sleep disturbances. Acupuncture, distinguished by its unique concepts and treatment methodologies, has undergone extensive experimentation, establishing its credibility in AD treatment. Significant strides have been achieved in understanding the neurobiological mechanisms underlying acupuncture’s efficacy in AD treatment, highlighting its favorable outcomes and distinctive benefits. This review initially outlines the pathogenesis of AD and subsequently delves into the research advancements in acupuncture’s role in AD treatment. This encompasses the impact of acupuncture on in vivo changes in biochemical indicators related to AD and the specific mechanisms by which it exerts therapeutic effects. Concurrent alterations in relevant AD indicators further affirm the efficacy of acupuncture treatment. Both clinical and mechanistic studies on acupuncture’s role in AD treatment are intensifying to meet the demands of social development. It is anticipated that as research progresses, acupuncture will attain new milestones in AD treatment.


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