NIH Library of Medicine PubMed Central
Journal List Front Aging Neurosci PMC10020224
With the ongoing trend of an aging population, Alzheimer’s disease (AD) has emerged as a pressing global medical concern. Cognitive decline in individuals with AD results in a diminished capacity for daily activities, coupled with behavioral and personality abnormalities, leading to disruptive psychiatric symptoms that significantly impact patients’ daily lives. Presently, pharmaceutical interventions are the primary approach in clinical management of AD; however, a substantial number of patients experience ineffectiveness of drugs, and some medications even induce severe sleep disturbances. Acupuncture, distinguished by its unique concepts and treatment methodologies, has undergone extensive experimentation, establishing its credibility in AD treatment. Significant strides have been achieved in understanding the neurobiological mechanisms underlying acupuncture’s efficacy in AD treatment, highlighting its favorable outcomes and distinctive benefits. This review initially outlines the pathogenesis of AD and subsequently delves into the research advancements in acupuncture’s role in AD treatment. This encompasses the impact of acupuncture on in vivo changes in biochemical indicators related to AD and the specific mechanisms by which it exerts therapeutic effects. Concurrent alterations in relevant AD indicators further affirm the efficacy of acupuncture treatment. Both clinical and mechanistic studies on acupuncture’s role in AD treatment are intensifying to meet the demands of social development. It is anticipated that as research progresses, acupuncture will attain new milestones in AD treatment.
隨著社會老齡化的發展趨勢，阿茲海默症（AD）已經成為全球醫學領域的一個迫切問題。AD患者的認知障礙導致日常生活能力下降，行為和個性異常，引起異常的精神症狀，嚴重影響患者的日常生活。目前，臨床上主要使用藥物治療AD患者，但很大一部分患者會出現藥物療效不佳，甚至一些藥物會引起嚴重的睡眠障礙。針灸以其獨特的理念和治療方法，通過大量實驗驗證了其在AD治療中的可靠性。在針灸治療AD的神經生物學機制研究中取得了許多進展，進一步證明了針灸在AD治療中的良好療效和獨特優勢。本綜述首先總結了AD的發病機制，然後說明了針灸在AD治療中的研究進展，包括針灸對AD體內生化指標變化的影響以及發揮治療效果的具體機制。AD相關指標的變化進一步驗證了針灸治療的有效性。針灸在AD治療中的臨床和機制研究正在加劇，以滿足社會發展的需求。相信隨著研究的進展，針灸將在AD治療方面取得新的成就。
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